Macvector

MacVector Installers and Updaters Which installer do I need? The latest version of MacVector that you can run is determined by the maintenance end date of your license. You can find this by running MacVector and choosing the MacVector | About MacVector menu item; Typically, the maintenance end date is set to 12 months after the last time that you or your institution last purchased MacVector, an upgrade, or renewed a yearly maintenance contract. If you believe the displayed date is incorrect, please check that you entered the most recent activation code sent from [email protected]. Next, look in the table below and find the most recent installer that your license can run; If the maintenance end date is more recent than this date Use this installer 1st June 2024 MacVector 18.7.1 1st July 2023 MacVector 18.6.4 1st November 2022 MacVector 18.5.1 1st August 2021 MacVector 18.2.5 1st February 2021 MacVector 18.1.5 1st December 2020 MacVector 18.0.1 1st February 2020 MacVector 17.5.4 1st November 2018 MacVector 17.0.10 1st September 2017 MacVector 16.0.10 1st February 2017 MacVector 15.5.3 1st August 2016 MacVector 15.1.5 1st June 2016 MacVector 15.0.2 1st November 2015 MacVector 14.5.3 1st February 2015 MacVector 14.0.6 1st September 2014 MacVector 13.5.5 1st November 2013 MacVector 13.0.7 1st October 2012 MacVector 12.7.5 1st May 2012 MacVector 12.6 1st October 2011 MacVector 12.5.1 1st December 2010 MacVector 12.0.6 1st December 2009 MacVector 11.1.2 1st July 2009 MacVector 11.0.4 1st March 2009 MacVector 10.6.0 1st October 2008 MacVector 10.5.3 1st January 2008 MacVector 10.0.2 1st April 2007 MacVector 9.5.4 Older Installers and Updaters These releases will only run on very old operating systems and hardware. They require the old purple USB hardware dongles to run. It is unlikely you will ever need to download and install these unless you have some very specific requirements and have discussed your needs with MacVector Support personnel. MacVector 9.0.2 MacVector 8.1 MacVector 7.2.3

That all we do keeps MacVector future proof and to be a modern macOS application that you can rely on.How to upgrade to MacVector 18.5If you have a maintenance contract that was active on 1st November, 2022, then you can install MacVector 18.5. You must be running macOS High Sierra to macOS Ventura. You will be prompted to automatically update within the next few days.You can also download the installer and do it manually now.If you have an older version of MacVector then download the trial and request an upgrade quote.Even if you have downloaded the trial in the past then downloading a new trial will give you a fresh 21 days to evaluate MacVector.When a trial license expires it becomes MacVector Free. So if you decide against upgrading then you can just delete the trial license and easily go back to your current version. It’s risk free as MacVector files are backwards compatible. MacVector 18.5 is macOS Ventura ready By Chris | Published: October 25, 2022 It’s that time of year again. Apple have just released macOS Ventura and we are very pleased to announce our current release, MacVector 18.2 has been tested on macOS Ventura and is compatible.Not only that but we have just a few weeks of testing left before our next release. MacVector 18.5 has been developed on macOS Ventura since the first developers beta build was available. MacVector 18.5 has been extensively tested on macOS Ventura too.Compatibility of previous versionsFor versions of MacVector before the current one you can check compatibility on a table which we update after every official release of macOS. For versions of MacVector released over the past few years it is likely that they will work fine. Our developers strive to future proof MacVector, and it is only when Apple make

Significant changes that older versions may stop working.Such significant changes include:MacVector 13.5 and all older versions will not run on macOS Catalina and earlier. This is due to Apple moving fully to a 64 bit operating system.MacVector 14.0 relies on an Apple library that Apple removed in MacOS Big Sur and later macOS releases. MacVector is macOS Ventura ready By Chris | Published: October 25, 2022 It’s that time of year again. Apple have just released macOS Ventura and we are very pleased to announce our current release, MacVector 18.2 is macOS Ventura ready.Not only that but we have just a few weeks of testing left before our next release. MacVector 18.5 has been developed on macOS Ventura since the first developers beta build was available. MacVector 18.5 has been extensively tested on macOS Ventura too.Compatibility of previous versionsFor versions of MacVector before the current one you can check compatibility on a table which we update after every official release of macOS. For versions of MacVector released over the past few years it is likely that they will work fine. Our developers strive to future proof MacVector, and it is only when Apple make significant changes that older versions may stop working.Such significant changes include:MacVector 13.5 and all older versions will not run on macOS Catalina and earlier. This is due to Apple moving fully to a 64 bit operating system.MacVector 14.0 relies on an Apple library that Apple removed in MacOS Big Sur and later macOS releases. MacVectorTip: Create custom Codon Usage Tables for ORF analysis and reverse translation By Chris | Published: October 19, 2022 MacVector uses codon usage tables (also called “Codon Bias”) to help you predict protein coding regions in the Analyze | Nucleic Acid Analysis Toolbox functions and also the protein Analyze | Reverse Translation...

To align DNA sequences based on their amino acid translations and multiple protein sequences can now be aligned to a single reference protein sequence.Translated Multiple Sequence Alignments: Align DNA sequences based on their amino acid translations. Display DNA sequences and their translations at the same time. Align the protein sequences using ClustalW, Muscle or T-Coffee to see the effect on the underlying DNA sequences. Directly edit the DNA sequences and immediately see the impact of the change on the amino acid alignments.Align proteins against a reference: You can use a protein sequence as a reference so that the display keys off that sequence when showing similarities. This allows you to view proteins in a similar way to the DNA Align To Reference interface.Applescript and Auto Annotate: Auto-annotation has joined the growing number of MacVector tools that support Applescript. Batch annotate folders of blank sequences. Example scripts provided.Check out the release notes for full details of this release.How to update to MacVector 15If you have active maintenance and are running MacVector 13.0.1 or later then you should have been notified about the new release already. At that point you have the option to automatically upgrade to MacVector 15. To install this version, you must have a maintenance contract that was active on 1 June 2016. If you are running OS X 10.6.8, the semi-automatic updater is not supported and you should download the full updater direct.If you have an older version of MacVector then download the trial and request an upgrade quote.If have downloaded the trial in the past then downloading a new trial will give you a fresh 21 days to evaluate MacVector even if a previous trial license had expired.Remember that when a trial expires it becomes MacVector Free. Posted in Releases | Tagged releases

Are using MacVector 15.0.1 or later, you will find that this interface has had some significant tweaks. First, a new CRISPR Indel Detection mode has been added to the Align To Reference settings dialog. This largely removes any need to adjust the individual settings;The second change is that a clean up step has been added to the alignment algorithm to minimize the number of gapped segments in the final alignment. This has the effect of dramatically cleaning up the region around the indels. Compare the alignment below to the previous MacVector 14.5.3 generated alignment;This is an article in a long running series of tips to help you get the most out of MacVector. If you want to get notified every time a new tip gets published, follow us @MacVector on twitter (or check the feed for the hashtag #101MacVectorTips) or like us on Facebook. How to use Codon Preference plots By Chris | Published: August 16, 2016 When you are looking for open reading frames in newly sequenced regions, it’s not always the longest ORFs that are protein-encoding. Lets look at an example from one of the sequences included with MacVector:/Applications/MacVector/Sample Files/Gal Cosmid.nucl.This is from Streptomyces coelicolor, a filamentous bacteria with a 73% G+C content. The high G+C% means that stop codons (TAA, TAG and TGA) occur relatively infrequently by chance, so long open reading frames are quite common. Look at this plot from an Analyze | Nucleic Acid Toolbox plot;You can see there is a long open reading frame in the top most pane in Frame +3. However, this is extremely unlikely to actually encode a functional protein. How do we know? Take a look at the Staden Codon Preference plots in panels 3 and 4. These plot the probability that each of the three frames encodes a protein

MacVector 18.5.1 Chris | Published: December 21, 2022 We’ve just released a minor update, MacVector 18.5.1.Changes include:Further enhancements for importing Sequencher projects (.spf) including heavily edited assemblies.A new setting for always opening MacVector in “light” mode even when macOS switches to “dark” mode.Easier remote activation of standard licenses for larger sites.increased number of seats for serverless network licenses.You will be automatically promoted to update. or go to FILE | CHECK FOR UPDATES… to update now.You can download the full installer instead.For assistance with remove activation of standard licenses please contact support. MacVector 18.5 has just been released and is macOS Ventura ready! By Chris | Published: November 11, 2022 It’s that time of year again. Apple have released macOS Ventura and we are very pleased to announce MacVector 18.5 is out. MacVector 18.5 is fully macOS Ventura ready!macOS Ventura readyMacVector 18.5 was developed and tested on macOS Ventura. It is supported on macOS High Sierra to macOS Ventura.MacVector 18.5 is a Universal Binary application and will run natively on Apple Silicon M1 and M2 Macs as well as Intel Macs.Heterozygote Analysis of Sanger trace filesThe heterozygote analysis tool analyzes one or multiple Sanger trace files and reports on all possible heterozygotes.You can also analyze Sanger trace files and permanently change the basecalled sequence with an IUPAC ambiguity code representing the basecalled heterozygote.The tool works on multiple trace files in the Assembly project manager or the Align to Reference editor.You can also basecall heterozygotes in a trace file in the Single Trace Editor.Align to Reference supports long readsLong sequencing reads from PacBio and ONT sequencers can now be assembled in Align to Reference. Miscellaneous enhancementsImporting Sequencher project (.SPF) files has been significantly enhanced.As usual there’s many bug fixes and changes that you probably don’t care too much about! But be assured